How do you reduce lipoprotein a Lp A?

To achieve Lp(a) reduction, one evidence-based approach is to initiate therapy with low-dose aspirin and extended-release niacin, titrated from 0.5 g up to 2 g over several weeks.

Is LP A the same as lipoprotein?

However, Lp(a) does… Lipoprotein (a) or Lp(a) is one type of lipoprotein that carries cholesterol in the blood. It consists of a low-density lipoprotein (LDL) molecule with another protein (Apolipoprotein (a)) attached to it.

Do statins reduce Lp A?

This might be due to the fact that statins do not optimally reduce all atherogenic lipoproteins, such as lipoprotein(a) (Lp[a]). Lp(a) is a genetic, independent, and likely causal risk factor for CVD [1,2].

Which drug reduces LP A?

However, statins are the most used medication for lowering heart attack and stroke risk in general, and so they are the most used medicine to treat risk from elevated Lipoprotein (a). Niacin can lower Lipoprotein (a) levels by 25-‐40%, as can PCSK9 inhibitors, but both are used less often.

How do you treat high Lp A?

The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials.

What happens if lipoprotein A is high?

High levels of LP(a) have now been identified as an independent risk factor in cardiovascular disease, with a causal link to atherosclerosis (furring up of arteries), heart attacks, strokes, aortic valve disease and heart failure.

Which is the best treatment for lipoprotein a?

Since no established treatment reduces Lp (a) without influencing other lipoproteins, there has been no trial that evaluated whether decreasing Lp (a) concentrations translates to clinical benefits. Recently, an antisense oligonucleotide against apo (a), IONIS-APO (a)Rx, has been shown to selectively decrease Lp (a) by almost 80%.

What is the normal level of lipoprotein ( LP )?

Normal Lp (a) levels are considered to be less than 25 mg/dL, with significant risk of atherothrombotic events beginning at levels between 50 and 70 mg/dL and rising thereafter. And that risk is not at all rare: 64 million U.S. residents have an Lp (a) level of 60 mg/dL or higher.

How is lipoprotein apheresis used to lower LDL?

Lipoprotein apheresis, a dialysis like procedure that is performed in some people on a biweekly basis, can lower both LDL and Lp (a) is sometimes used to lower Lp (a). Finally, there are a number of Lp (a) lowering medications in clinical trials now. We will wait to see the outcomes of these trials in the next few years.

What are the effects of high lipoprotein levels?

Like LDL cholesterol, high levels have been linked to an increased risk of heart disease and stroke. Lp (a) levels are largely determined by genetics. However, emerging studies have found that lifestyle and dietary modification can positively affect Lp (a).

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