Is there such a thing as a seminoma?

A Seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations.

Can a seminoma be found in the mediastinum?

A Seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered in early stages. Testicular seminoma originates in the germinal epithelium of the seminiferous tubules.

Which is the initial event in the origin of seminoma?

The initial event in the origin of seminoma is the malignant transformation of an intratubular germ cell. This process is analogous to intraepithelial or carcinoma in situ in other organs, but as gonocytes are not epithelial cells, the accurate terminology is intratubular germ cell neoplasia, unclassified (ITGCNU).

Which is the only marker that elevated in seminoma?

Lactate dehydrogenase (LDH) may be the only marker that is elevated in some seminomas. The degree of elevation in the serum LDH has prognostic value in advanced seminoma. The cut surface of the tumour is fleshy and lobulated, and varies in colour from cream to tan to pink.

What is the etiology of testicular seminoma?

Etiology. Etiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). Cryptorchidism is a risk factor for the development of testicular seminomatous germ cell tumors.

What’s the difference between choriocarcinoma and seminoma?

Choriocarcinomas are extremely rare but highly aggressive tumors accounting for less than 1% of the total testicular tumors. They do not give rise to an enlargement of the testicles and will be presented as a palpable nodule. There are two cell types in these tumors as syncytiotrophoblasts and cytotrophoblasts.

What are the symptoms of Stage 1 seminoma?

Stage 1 seminoma is characterized by the absence of clinical evidence of metastasis. Active surveillance consists of periodic history and physical examinations, tumor marker analysis, and radiographic imaging. Around 85-95% of these cases will require no further treatment.