What is the function of PPAR gamma?

Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function.

Is PPAR gamma good?

Besides an impact on weight gain, reduced fluid retention may also lower the risk for adverse cardiovascular events, such as congestive heart failure. Although it is expressed at low levels in the heart, the expression of PPARγ is increased in the hearts of humans with metabolic syndrome84.

What is the function of PPAR alpha?

PPAR-α is a transcription factor and a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation and is necessary for the process of ketogenesis, a key adaptive response to prolonged fasting.

What activates PPAR?

Endogenous ligands for the PPARs include free fatty acids, eicosanoids and Vitamin B3. PPARγ is activated by PGJ2 (a prostaglandin) and certain members of the 5-HETE family of arachidonic acid metabolites including 5-oxo-15(S)-HETE and 5-oxo-ETE.

Is PPAR gamma a transcription factor?

PPAR-γ: a thrifty transcription factor.

What is adiponectin function?

Adiponectin is a fat-derived hormone that appears to play a crucial role in protecting against insulin resistance/diabetes and atherosclerosis. Decreased adiponectin levels are thought to play a central role in the development of type 2 diabetes, obesity and cardiovascular disease in humans.

What is the mechanism of action of thiazolidinediones TZDs?

Mechanism of action Thiazolidinediones or TZDs act by activating PPARs (peroxisome proliferator-activated receptors), a group of nuclear receptors, specific for PPARγ (PPAR-gamma, PPARG). They are thus the PPARG agonists subset of PPAR agonists.

How do PPAR alpha agonists work?

PPARγ agonists promote adipocyte differentiation, and they promote FFA uptake and storage in subcutaneous adipose rather than visceral adipose tissue. This reduces FFA levels, with associated reductions in insulin resistance.

What activates PPAR alpha?

PPAR-α can be activated by certain natural and synthetic ligands such as PUFAs, eicosanoids, and hypolipidemic drugs (fibrates) and then modulates DNA transcription by binding to specific nucleotide sequences located in the regulatory regions of target genes known as peroxisome proliferator responsive elements (PPREs)6 …

How do PPAR agonists work?

What is the function of PPAR?

Peroxisome proliferator-activated receptor (PPAR)-alpha is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPAR-alpha regulates the expression of genes involved in fatty acid beta-oxidation and is a major regulator of energy homeostasis.

What activates PPAR gamma?

The phytocannabinoid cannabidiol (CBD) has been shown to activate PPAR gamma in in vitro and in vivo models. The cannabinoid carboxylic acids THCA, CBDA and CBGA activate PAARy more efficient than their decarboxylated products; however, THCA was the acid found with highest activity.

Which is the best antibody for phospho PPAR alpha?

Overview Product name Anti-PPAR alpha (phospho S12) antibody Description Rabbit polyclonal to PPAR alpha (phospho S12) Host species Rabbit Specificity The antibody is expected to bind both phospho and non phospho forms. Tested applications Suitable for: ICC/IF, WB, Flow Cytmore details Species reactivity Reacts with: Mouse, Rat, Human

Can a PPARγ antibody be used in CST?

Western blot analysis of extracts from NIH/3T3 and NIH/3T3-L1 cells (differentiated 6 days) using PPARγ (D69) Antibody. This product has been approved for use in this application by CST.

Which is peroxisome proliferator activated receptor γ ( PPARγ )?

Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator (1). PPARγ is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage (2).

Where is PPARγ found in smooth muscle cells?

PPARγ is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage (2). Besides its role in mediating adipogenesis and lipid metabolism (2), PPARγ also modulates insulin sensitivity, cell proliferation and inflammation (3).