What intercostal space is the spleen?

The size of the spleen was largest at the 7th and 8th intercostal spaces and the maximum thickness was measured at the 9th to 12th intercostal spaces. The liver was seen in all calves on the right and could be imaged at the 5th to 12th intercostal spaces and the area caudal to the last rib.

Can you check your own spleen?

Palpation for splenic enlargement should begin with the patient supine and with knees flexed. Using the right hand, the examiner should begin well below the left costal margin and feel gently but firmly for the splenic edge by pushing down, then cephalad, then releasing (Figure 150.1).

How do you check your own spleen?

Technique

1. Start in RLQ (so you don’t miss a giant spleen).
2. Get your fingers set then ask patient to take a deep breath.
3. When patient expires, take up new position.
4. Note lowest point of spleen below costal margin, texture of splenic contour, and tenderness.
5. If spleen is not felt, repeat with pt lying on right side.

Where was halichondrin B isolated from a sponge?

The complex marine polyether halichondrin B (Figure 5.17) was first isolated from a Japanese sponge by Uemura and his colleagues [250], and was subsequently isolated again by Pettit from an Axinella sp. collected in Palau [251].

What kind of microlide is halichondrin B?

Halichondrin B is a complex polyether macrolide isolated from the marine sponge Halichondria okadai, with an extraordinarily high potency as an antitumor agent and a high therapeutic index.

What kind of drug is halichondrin B from?

Halichondrin B is a complex polyether macrolide isolated from the marine sponge Halichondria okadai, with an extraordinarily high potency as an antitumor agent and a high therapeutic index. From: Medicinal Chemistry of Anticancer Drugs, 2008.

How many decane core does halichondrin have?

The halichondrin family of natural products is characterized by a highly complex architecture featuring a 2,6,9-trioxatricyclo [3.3.2.0] decane core as well as exquisitely potent antiproliferative activity (minimal efficacious doses in in vivo xenograft studies are in the microgram per kilogram range).