What is Refludan used for?

Refludan (lepirudin) is a direct inhibitor of thrombin, which works by keeping the platelets in the blood from coagulating (clotting) to treat or prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Is lepirudin still used?

Bayer announced that it ceased the production of lepirudin (Refludan) on May 31, 2012.

Is lepirudin available in the US?

After careful consideration, Bayer HealthCare would like to inform you that we will discontinue marketing Refludan® [lepirudin (rDNA) for injection] on May 31, 2012 and no further product is expected to be shipped to wholesalers in the United States after that date.

What is the antidote for lepirudin?

There is no specific antidote against lepirudin or any of the other hirudin derivatives. This is a major issue in areas where high anticoagulant activity may be required, particularly in cardiovascular surgery with extracorporeal circulation.

Is fondaparinux an anticoagulant?

Fondaparinux (Arixtra) is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin (AT) binding region of heparin. Similar to low molecular weight heparins, it is an indirect inhibitor of factor Xa, but it does not inhibit thrombin at all.

What is the difference between fondaparinux and enoxaparin?

Fondaparinux is a factor Xa inhibitor and does not inhibit thrombin (IIa) [8]. Enoxaparin on the other hand, binds to antithrombin to form a complex molecule that can irreversibly inactivate clotting factor Xa and it has less activity against thrombin [9]. This is how these two anticoagulants work.

How much Lepirudin is in a vial of Refludan?

Each vial of Refludan contains 50 mg lepirudin. Other ingredients are 40 mg mannitol and sodium hydroxide for adjustment of pH to approximately 7. The pharmacokinetic properties of lepirudin following intravenous administration are well described by a two-compartment model.

What do you need to know about Refludan injection?

Refludan Description. Refludan [lepirudin (rDNA) for injection] is a highly specific direct inhibitor of thrombin. Lepirudin, (chemical designation: [Leu1, Thr2]-63-desulfohirudin) is a recombinant hirudin derived from yeast cells. The polypeptide composed of 65 amino acids has a molecular weight of 6979.5 daltons.

When do the Bayer plus rewards expire?

Growers must have at least $1,500 in Bayer PLUS Rewards rebates at the time of redemption to claim incentive. Growers can earn incentives on up to five eligible products in the Product Portfolio Incentives. 100% of rewards may be requested starting November 1, 2021. Rewards will expire April 30, 2022.

Do you have to sign up for Bayer plus every year?

Signing up is easy! A few simple steps and you’ll be growing rewards in no time. If you are currently enrolled in Bayer PLUS, you will not have to re-enroll every year. Your membership will automatically carry over to the new program year. Have your Technology ID handy.