How do you take Rapamune?

So, always take sirolimus before a meal, or always take your doses after a meal. Swallow the tablets whole with a drink of water. If you have been given the oral solution, measure out your dose using a dose syringe provided and then add it into a glass of water or orange juice.

What is the drug Rapamune used for?

Rapamune (sirolimus) is an immunosuppressive agent used to prevent your body from rejecting a transplanted kidney. Rapamune is sometimes used in a combination treatment with cyclosporine and a steroid medicine such as prednisone.

What is the generic brand for Rapamune?

GENERIC NAME: SIROLIMUS – ORAL (sir-oh-LEE-muss)

How much rapamycin should I take?

The maximum Rapamune dose administered on any day should not exceed 40 mg. If an estimated daily dose exceeds 40 mg due to the addition of a loading dose, the loading dose should be administered over 2 days. Sirolimus trough concentrations should be monitored at least 3 to 4 days after a loading dose(s).

Is Rapamune the same as rapamycin?

Sirolimus, also known as rapamycin or by the brand name Rapamune, is a medicine that lowers the body’s natural immunity. The immune system response is thought to be involved in Nephrotic Syndrome. It is also used to prevent rejection of transplanted organs, such as the kidney, heart, and liver.

Can you split sirolimus tablet?

Do not crush, chew, or break a sirolimus tablet. Tell your doctor if you have trouble swallowing the tablet whole.

What are the benefits of rapamycin?

Rapamycin (Sirolimus) slows aging, extends life span, and prevents age-related diseases, including diabetic complications such as retinopathy. Puzzlingly, rapamycin can induce insulin sensitivity, but may also induce insulin resistance or glucose intolerance without insulin resistance.

What foods contain rapamycin?

Spermidine—a compound found in foods like aged cheese, mushrooms, soy products, legumes, corn and whole grains—seems to prevent (at least in animal models) liver fibrosis and hepatocellular carcinoma, which is the most common type of liver cancer.

Does rapamycin increase aging?

When taken late in life, rapamycin increases lifespan by 9-14% [155], despite the dosage being suboptimal [111]. This possibly equates to more than 7 years of human life. By comparison, smokers who quit late in life (at age 65 years), gain between 1.4 -3.7 years [172].

Is there a natural alternative to rapamycin?

In particular, they identified allantoin and ginsenoside as strong mimetics of metformin, epigallocatechin gallate and isoliquiritigenin as strong mimetics of rapamycin, and withaferin A as a strong mimetic of both.

Does rapamycin reverse aging?

Although rapamycin may reverse some manifestations of aging [181,193], it is more effective at slowing down aging than reversing it. Therefore, rapamycin will be most effective when administered at the pre-disease, or even pre-pre-disease stages of age-related diseases [150].

What happens if you stop taking sirolimus?

Stopping suddenly could make your condition worse. Store sirolimus tablets at room temperature, away from heat, moisture, and light. Store sirolimus liquid in the refrigerator. Do not freeze.

What should be the maximum daily dose of Rapamune?

How many milligrams of Rapamune to take after sirolimus trough?

Sirolimus trough concentrations should be monitored at least 3 to 4 days after a loading dose (s). Two milligrams (2 mg) of Rapamune Oral Solution have been demonstrated to be clinically equivalent to 2 mg Rapamune Tablets; hence, at this dose these two formulations are interchangeable.

How long does it take to adjust Rapamune maintenance dose?

Once Rapamune maintenance dose is adjusted, patients should continue on the new maintenance dose for at least 7 to 14 days before further dosage adjustment with concentration monitoring. In most patients, dose adjustments can be based on simple proportion: new Rapamune dose = current dose × (target concentration/current concentration).

How often should you take Rapamune for lymphangioleiomyomatosis?

For patients with lymphangioleiomyomatosis, the initial Rapamune dose should be 2 mg/day. Sirolimus whole blood trough concentrations should be measured in 10-20 days, with dosage adjustment to maintain concentrations between 5-15 ng/mL [see Dosage and Administration (2.5)].