How much does a vancomycin trough cost?

The vancomycin TDM cost of $109 was estimated by including the cost of phlebotomy ($40 per draw) and cost of vancomycin trough measurement ($69 per concentration measurement).

How do you calculate vancomycin ke?

Again, based on population kinetics, it has been determined that we can estimate k e with the equation 0.00083*CrCl + 0.0044.

How do you calculate Cmax vancomycin?

Using the first-order elimination equation (Cp=Cp0∗e−kt), a true peak (Cmax) can be calculated using the time elapsed between the end of the vancomycin infusion and the first drug concentration (Cp0).

How do you calculate half life for vancomycin?

Other pharmacists use the half-life (t1/2) equation (t1/2 = 0.693/Kel) to estimate how long to wait to reach the goal trough, using the Matzke equation to calculate the elimination constant (Kel) for vancomycin1: Kel=0.00083×(CrCl)+0.0044, Thus,t1/2=0.6930.00083×(CrCl)+0.0044.

How do you interpret a vancomycin trough?

Trough concentrations are recommended for therapeutic monitoring of vancomycin, preferably acquired at steady-state (just before fourth dose). To avoid development of resistance, vancomycin trough levels should remain above 10.0 mcg/mL. Complicated infections require higher target levels, typically 15.0 to 20.0 mcg/mL.

Can IV vancomycin be given at home?

You may receive vancomycin injection in a hospital or you may use the medication at home. If you are using vancomycin injection at home, use it at around the same time every day.

How long does vancomycin stay in your system?

In healthy patients, the half-life of vancomycin is between 4 to 6 hours; in patients lacking functional kidneys, the half-life can be as long as 7.5 days.

What is the desired peak for vancomycin?

Target ranges for serum vancomycin concentrations have changed over the years. Early authors suggested peak levels of 30 to 40 mg/l and trough levels of 5 to 10 mg/l, but current recommendations are that peak levels need not be measured and that trough levels of 10 to 15 mg/l or 15 to 20 mg/l,…

What is the trough level of vancomycin?

Vancomycin is a glycopeptide antibiotic, typically used for treatment of MRSA . Traditionally it is recommended to get trough doses to assess efficiency. Typically, we aim for Vancomycin trough levels between 10-20µg/mL (15-20 µg/mL for more severe infections).

What is the half life of vancomycin?

The mean elimination half-life of vancomycin from plasma is 4 to 6 hours in subjects with normal renal function. In the first 24 hours, about 75% of an administered dose of vancomycin is excreted in urine by glomerular filtration. Mean plasma clearance is about 0.058 L/kg/h, and mean renal clearance is about 0.048 L/kg/h.

What is the dose of vancomycin?

The usual intravenous dosage of vancomycin is 10 mg/kg per dose given every 6 hours. Each dose should be administered over a period of at least 60 minutes. Close monitoring of serum concentrations of vancomycin may be warranted in these patients.