How do anticholinergics affect the detrusor muscle?

Anticholinergic agents prevent involuntary contractions of the bladder detrusor muscle by preventing acetylcholine from binding to the M2 and M3 muscarinic receptor subtypes.

What is the treatment given to a person with detrusor hyperactivity?

Oxybutynin and tolterodine are the more commonly used anticholinergics in OAB treatment. Oxybutynin (Ditropan) was among the first anticholinergic agents to be used to treat detrusor overactivity, and its efficacy in treating OAB is well documented.

What are the side effects of oxybutynin?

Oxybutynin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• dry mouth.
• blurred vision.
• dry eyes, nose, or skin.
• stomach pain.
• constipation.
• diarrhea.
• nausea.
• heartburn.

What does detrusor instability mean?

Detrusor instability is a urodynamic diagnosis made when the detrusor is shown objectively to contract, spontaneously or on provocation, during the filling phase of a cystometrogram while the patient is attempting to inhibit micturition.

What is meant by detrusor instability?

Detrusor instability is a common cause of urgency and urge incontinence in neurologically normal patients. It is defined as an involuntary phasic detrusor contraction of any pressure associated with symptoms of urge or leakage while the patient is attempting to inhibit micturition.

What kind of medication do you take for detrusor instability?

The drugs of choice are anticholinergic drugs like oxybutynin which tend to relax the muscles of the bladder thus reducing involuntary detrusor muscle contractions and increase bladder capacity. These medications are added depending on the severity of the symptoms and the duration of them.

What are the signs and symptoms of detrusor instability?

Some of the symptoms of Detrusor Instability are: 1 Increased urinary frequency 2 Nocturia 3 Pain or discomfort in the abdominal area 4 Urinary urge incontinence, more prevalent in females.

Are there any alternatives to oxybutinin for detrusor instability?

Oxybutin is however associated with a high incidence of side effects which limits its use. Modified release oxybutinin, propiverine and tolderodine may be considered as an alternative for patients unable to tolerate conventional-release oxybutinin (1)

How is detrusor instability related to overactive bladder syndrome?

What is Detrusor Instability? Detrusor Instability which is also known by the name of Overactive bladder Syndrome is a pathological condition of the bladder in which the affected individual experiences increased urinary urgency along with frequency and nocturia with at times urinary incontinence as a result of instability of the detrusor muscle.