Is hydroxypropyl beta cyclodextrin toxic?

This review concludes that HP-beta-CD is well tolerated in the animal species tested (rats, mice and dogs), particularly when dosed orally, and shows only limited toxicity.

Is cyclodextrin safe for humans?

Cyclodextrins alone are poorly absorbed transdermally, but in combination with absorption-promoting agents, they are able to permeate the skin by 12%, 43%, and 53% for β-CD, RM-β-CD, and HP-β-CD, respectively. Concentrations up to 0.1% of α-, β-, and γ-cyclodextrins are considered safe.

Is beta cyclodextrin soluble in water?

Beta-cyclodextrin is the least soluble cyclodextrin in water. At high pH, ionization of hydroxyl groups increases water solubility; at pH 12.5 the solubility of β-cyclodextrin is 750 g/L. 38,39. Cyclodextrins are insoluble in most organic solvents (Table 22.3).

What is special about beta cyclodextrin?

β-Cyclodextrin, a cyclic oligosaccharide consisting of seven glucose units joined as α-(1 → 4) isomers, is nontoxic, edible, nonhygroscopic, chemically stable, and easily separable. It has a cavity at the center of the molecular arrangement and can thus form a stable insoluble inclusion complex with cholesterol.

What is beta cyclodextrin used for?

Cyclodextrins, and expecially beta ones, are widely used in the pharmaceutical field for their ability of improving the solubility and the stability of drugs by complex formation at the solid state.

What is the function of beta cyclodextrin?

What causes the solubility of beta cyclodextrin to decrease?

A completely cyclic hydrogen bond is formed in the molecule of the beta cyclodextrin, which makes the molecule quite rigid, leading to its decrease in the solubility of water.

How are cyclodextrins soluble in water and miscible solvents?

Cyclodextrins are somewhat soluble in mixtures of water and water-miscible organic solvents. In general, as the concentration of the organic solvent increases, the solubility of the cyclodextrin decreases.

How is beta cyclodextrin different from dextrin and Alfa?

From the thermodynamic point of view, beta cyclodextrin has a ring of thermodynamic properties of dextrin, gamma cyclodextrin is different from Alfa, its interaction with water to make the system less of the unsuitable particle, entropy compensation suitable enthalpy, resulting beta cyclodextrin solubility decreased significantly.

How does the presence of urea increase the solubility of cyclodextrin?

Interference with the hydrogen bonding of the hydroxyl groups increases the water solubility of the cyclodextrins. In the presence of urea, the solubility of β-cyclodextrin increases to 250 g/L. 38 At high pH, ionization of hydroxyl groups increases water solubility; at pH 12.5 the solubility of β-cyclodextrin is 750 g/L. 38,39